HBOT Therapy

Is HBOT Safe? Side Effects and
Contraindications

Overall Safety Profile

A Well-Established Safety Record

Hyperbaric Oxygen Therapy is generally considered very safe when delivered by trained staff under physician supervision. It has been in mainstream clinical use for more than five decades. Serious complications are uncommon. The most frequent side effects are mild and transient.

Every Evolve patient undergoes a physician-led pre-treatment assessment specifically to identify contraindications and modifiable risk factors before treatment begins.

Common Side Effects

Usually Mild and Transient

Ear pressure (middle ear barotrauma)

The most common side effect. As the chamber pressurizes, the air pressure inside the middle ear must equalize with the outside pressure — the same equalization required during airplane descent. Most patients learn equalization techniques (yawning, swallowing, gentle Valsalva) within their first one or two sessions. Our technicians coach you through this. If equalization is difficult, pressurization can be slowed.

Significant middle ear injury is uncommon. In patients who cannot equalize, an ENT consultation can be arranged, and ventilation tubes (myringotomy tubes) are sometimes placed to allow treatment to continue safely.

Temporary mild near-sightedness (myopia)

Some patients experience a temporary mild shift in vision toward near-sightedness during a course of HBOT. This is caused by transient changes in the shape of the eye’s lens under repeated high-oxygen exposure. The effect is reversible — vision typically returns to baseline within six to eight weeks of completing treatment. Patients are advised not to update their eyeglass prescription during treatment.

Mild fatigue

Some patients feel mildly tired after a session, particularly early in the treatment course. This typically resolves on its own and does not require any intervention.

Sinus pressure

Similar to ear pressure, sinuses must equalize during pressure change. Patients with an existing upper respiratory infection or significant sinusitis may experience discomfort; in those cases, sessions are postponed until symptoms resolve.

Rare Complications

Uncommon, and Actively Managed

Oxygen toxicity (CNS)

Rarely, prolonged high-oxygen exposure can produce neurologic symptoms — most notably a brief seizure. These are uncommon at the pressures and durations used in standard HBOT, but the risk is recognized. Patients are monitored throughout each session, and any concerning symptoms are addressed by immediately reducing pressure.

Pulmonary barotrauma

Extremely rare. Includes pneumothorax (collapsed lung) due to rapid pressure change in patients with pre-existing lung disease. Our pre-treatment assessment screens for risk factors, and pressurization protocols are gradual to minimize barotrauma risk.

Reduced blood sugar in insulin-treated diabetics

Patients on insulin should monitor blood glucose before and after sessions; HBOT can lower blood sugar in some patients. Our team reviews diabetes management with each insulin-treated patient before starting treatment.

Contraindications

Who Should Not Be
Treated — or Needs Review

Absolute contraindication

Untreated pneumothorax (collapsed lung). Any unresolved pneumothorax must be treated before HBOT can be considered.

Relative contraindications (require physician evaluation, may still be treatable):

Significant chronic obstructive pulmonary disease (COPD), bullous lung disease, or other severe lung pathology

Recent middle ear or sinus surgery

Uncontrolled seizure disorder

Active upper respiratory infection (defer treatment until resolved)

Certain chemotherapy agents (e.g., doxorubicin, bleomycin, cisplatin) — timing and combination require physician review

Pregnancy — generally not appropriate for the elective outpatient indications we treat; case-by-case discussion with the hyperbaric physician and obstetric team if HBOT is being considered

Severe claustrophobia — may be managed with familiarization sessions or, in select cases, a mild prescribed anxiolytic

Implanted devices — pacemakers, implantable cardioverter-defibrillators (ICDs), insulin pumps, and similar devices must be reviewed for pressure-rated suitability

Before Your Session

Pre-Session Checklist for Patients

Patients are advised to:

Eat a light meal one to two hours before treatment to maintain stable blood sugar

Stay well hydrated; avoid carbonated drinks for four hours before
Avoid alcohol for at least four hours before

Refrain from smoking and nicotine products throughout the treatment course — nicotine constricts blood vessels and reduces HBOT effectiveness
Wear no cosmetics, perfumes, lotions, petroleum-based products, or hair preparations (fire safety in an oxygen-enriched environment)

Remove jewelry, watches, hearing aids (we provide a secure place to store them), and any electronics
Inform our team about all current medications, including over-the-counter medications and supplements

Wear the 100% cotton scrubs we provide for treatment

In-Chamber Safety

What's Permitted Inside

Not permitted inside

  • Electronics
  • Jewelry
  • Watches
  • Hearing aids
  • Mobile phones
  • Lighters or other ignition sources
  • Alcohol-based products
  • Synthetic clothing or fabrics

Everything you need is provided

Our chambers have entertainment screens and audio that allow video and music during sessions — bringing personal devices into the chamber is not permitted, but everything you need is provided.

References

  1. Moon RE (ed.). Hyperbaric Oxygen Therapy Indications. 14th edition. North Palm Beach, FL: Best Publishing Company; 2019.
  2. Mathieu D, Marroni A, Kot J. Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment. Diving Hyperb Med. 2017 Mar;47(1):24–32.
  3. Heyboer M, Sharma D, Santiago W, McCulloch N. Hyperbaric oxygen therapy: side effects defined and quantified. Adv Wound Care (New Rochelle). 2017 Jun 1;6(6):210–224.
  4. CSA Z275.1: Hyperbaric facilities. CSA Group, Canada.
Medical review

Dr. Vik Agarwal MD CCFP FRCPC CAQ-HP — President, Evolve Medical Group

Dr. Seema Agarwal MD CCFP CAQ-HP — Chief Medical Officer, Evolve Hyperbarics

Last reviewed: May 2026 · Next: May 2027

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